Evaluating the Efficacy of Therapies in COVID-19 Patients

Clinical Infectious Diseases, ciaa1231, https://doi.org/10.1093/cid/ciaa1231
21 August 2020
 Article history
11 June 2020
21 August 2020


There is a proliferation of clinical trials worldwide to find effective therapies for patients diagnosed with novel coronavirus disease-2019 (COVID-19). The endpoints that are currently used to evaluate the efficacy of therapeutic agents against COVID-19 are focused on clinical status at a particular day or on time to a specific change of clinical status. To provide a full picture of the clinical course of a patient and make complete use of available data, we consider the trajectory of clinical status over the entire follow-up period. We also show how to combine the evidence of treatment effects on the occurrences of various clinical events. We compare the proposed and existing endpoints through extensive simulation studies. Finally, we provide guidelines on establishing the benefits of treatments.  https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1231/5895068?searchresult=1


By Roman Ribnikov especially for Medical Express

21.08.2020 1329

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